selected publications
Publications at smu
Snyder J, Wu Z. Origins of nervous tissue susceptibility to ferroptosis. Cell Insight. 2023 Jun;2(3):100091. doi: 10.1016/j.cellin.2023.100091. eCollection 2023 Jun. Review. PubMed PMID: 37398634; PubMed Central PMCID: PMC10308196.
Ho WS, Mondal I, Xu B, Das O, Sun R, Chiou P, Cai X, Tahmasebinia F, McFadden E, Wu CY, Wu Z, Matsui W, Lim M, Meng Z, Lu RO. PP2Ac/STRN4 negatively regulates STING-type I IFN signaling in tumor-associated macrophages. J Clin Invest. 2023 Mar 15;133(6). doi: 10.1172/JCI162139. PubMed PMID: 36757811; PubMed Central PMCID: PMC10014107.
Tang Y, Huang Y, Wan Z, Zhou B, Wu Z. Mitochondrial quality control links two seemingly unrelated neurodegenerative diseases. Autophagy. 2022 Oct;18(10):2495-2497. doi: 10.1080/15548627.2022.2094605. Epub 2022 Jul 12. PubMed PMID: 35786295; PubMed Central PMCID: PMC9542738.
Huang Y, Wan Z, Tang Y, Xu J, Laboret B, Nallamothu S, Yang C, Liu B, Lu RO, Lu B, Feng J, Cao J, Hayflick S, Wu Z, Zhou B. Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism. Nat Commun. 2022 May 3;13(1):2412. doi: 10.1038/s41467-022-30178-x. PubMed PMID: 35504872; PubMed Central PMCID: PMC9065001.
Wu Z, Ho WS, Lu R. Targeting Mitochondrial Oxidative Phosphorylation in Glioblastoma Therapy. Neuromolecular Med. 2022 Mar;24(1):18-22. doi: 10.1007/s12017-021-08678-8. Epub 2021 Sep 6. Review. PubMed PMID: 34487301.
Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 2021 Sep 22;10. doi: 10.7554/eLife.69795. PubMed PMID: 34550070; PubMed Central PMCID: PMC8457844.
Imai Y, Kim K, Wu Z, Sato S. Editorial: Molecular Links Between Mitochondrial Damage and Parkinson's Disease and Related Disorders. Front Cell Dev Biol. 2021;9:734475. doi: 10.3389/fcell.2021.734475. eCollection 2021. PubMed PMID: 34422843; PubMed Central PMCID: PMC8377497.
Publications before smu
Kim, G. H. J., Mo, H., Liu, H., Wu, Z., Chen, S., Zheng, J., ... & Guo, S. (2021). A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife, 10, e69795.
Li, S.*, Wu, Z.*, & Lu, B. (2021). Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Cell Reports, 32(5), 107989 (* co-first author)
Li, S., Wu, Z., Tantray, I., Li, Y., Chen, S., Dong, J., Glynn, S., Vogel, H., Snyder, M., & Lu, B. (2020). Quality-control mechanisms targeting translationally stalled and C-terminally extended poly (GR) associated with ALS/FTD. Proceedings of the National Academy of Sciences 117(40), 25104-25115.
Wu, Z., Tantray, I., Lim, J., Chen, S., Davis, Z., Sitron, C., Dong, J., Gispert, S., Auburger, G., Brandman, O., Bi, X., Snyder, M., & Lu, B. (2019). MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure. Molecular Cell, 75(4), 835-848.
Wu, Z.*, Wang, Y.*, Lim, J., Liu, B., Li, Y., Vartak, R., & Lu, B. (2018). Ubiquitination of ABCE1 by NOT4 Triggers the Recruitment of Autophagy Machinery in PINK1-Directed Mitophagy. Cell Metabolism, 28(1), 130-144. (* first author)
Wu, Z.*,#, Wu, A.*, Dong, J., Sigears, A., Lu, B. #. (2018). Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson’s disease through activation of mitophagy. Experimental Gerontology, 113, 10-17. (* first author; # co-corresponding author)
Lee, K., Huh, S., Lee, S., Wu, Z., Kim, A., Kang, H., & Lu, B. (2018) Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models. Proceedings of the National Academy of Sciences, 115(38), E8844-E8853.
Gehrke, S.*, Wu, Z.*, Klinkenberg, M., Sun, Y., Auburger, G., Guo, S., & Lu, B. (2015). PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane. Cell Metabolism, 21(1), 95-108. (* co-first author)
Lu, B., Gehrke, S., & Wu, Z. (2014). RNA metabolism in the pathogenesis of Parkinson׳ s disease. Brain Research, 1584, 105-115.
Wu, Z., Sawada, T., Shiba, K., Liu, S., Kanao, T., Takahashi, R., ... & Lu, B. (2013). Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. Genes & Development, 27(2), 157-162.
Lee, K. S.*, Wu, Z.*, Song, Y., Mitra, S. S., Feroze, A. H., Cheshier, S. H., & Lu, B. (2013). Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. Genes & Development, 27(24), 2642-2647. (* co-first author)
Huh, S., Lee, K. S., Lee, S., Wu, Z., and Lu, B. Altered ER–mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models. (2015). Proceedings of the National Academy of Sciences, 38(115), E8844-8863.
Huang, Y., Wu, Z., & Zhou, B. (2015). Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity. Cellular & Molecular Life Sciences, 1-21.
Huang, Y.*, Wu, Z.*, Cao, Y., Lang, M., Lu, B., & Zhou, B. (2014). Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Cell Reports, 8(3), 831-842. (* co-first author)
Cui, Y., Zhao, S., Wu, Z., Dai, P., & Zhou, B. (2012). Mitochondrial release of the NADH dehydrogenase Ndi1 induces apoptosis in yeast. Molecular Biology of the Cell, 23(22), 4373-4382.
Wu, Z., Du, Y., Xue, H., Wu, Y., & Zhou, B. (2012). Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production. Neurobiology of Aging, 33(1), 199-e1.
Wu, Z., Li, C., Lv, S., & Zhou, B. (2009). Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model. Human Molecular Genetics, 18(19), 3659-3672.
Yang, Y., Wu, Z., Kuo, Y. M., & Zhou, B. (2005). Dietary rescue of fumble — a Drosophila model for pantothenate-kinase-associated neurodegeneration. Journal of Inherited Metabolic Disease, 28(6), 1055-1064.